P2X7 Receptor and Extracellular Vesicle Release
Maria Teresa Golia, Martina Gabrielli, Claudia Verderio
Abstract
Extensive evidence indicates that the activation of the P2X7 receptor (P2X7R), an ATP-gated ion channel highly expressed in immune and brain cells, is strictly associated with the release of extracellular vesicles. Through this process, P2X7R-expressing cells regulate non-classical protein secretion and transfer bioactive components to other cells, including misfolded proteins, participating in inflammatory and neurodegenerative diseases. In this review, we summarize and discuss the studies addressing the impact of P2X7R activation on extracellular vesicle release and their activities.
Topics & Concepts
ExtracellularExtracellular vesicleCell biologySecretionExtracellular vesiclesVesicleReceptorImmune systemMicrovesiclesChemistryBiologyBiochemistryImmunologyMembraneGenemicroRNAAdenosine and Purinergic SignalingExtracellular vesicles in diseaseNeuroscience of respiration and sleep