Methylmercury toxic mechanism related to protein degradation and chemokine transcription
Jin‐Yong Lee, Gi-Wook Hwang, Akira Naganuma, Masahiko Satoh
Abstract
Methylmercury is an environmental pollutant that causes neurotoxicity. Recent studies have reported that the ubiquitin-proteasome system is involved in defense against methylmercury toxicity through the degradation of proteins synthesizing the pyruvate. Mitochondrial accumulation of pyruvate can enhance methylmercury toxicity. In addition, methylmercury exposure induces several immune-related chemokines, specifically in the brain, and may cause neurotoxicity. This summary highlights several molecular mechanisms of methylmercury-induced neurotoxicity.
Topics & Concepts
MethylmercuryNeurotoxicityChemokineToxicityProteasomeUbiquitinChemistryImmune systemBiologyCell biologyEnvironmental chemistryBiochemistryImmunologyGeneOrganic chemistryBioaccumulationMercury impact and mitigation studiesHeavy Metal Exposure and ToxicitySelenium in Biological Systems