Leishmania donovani Exploits Tunneling Nanotubes for Dissemination and Propagation of B Cell Activation
Tanja Stögerer, Sasha Silva‐Barrios, Liseth Carmona‐Pérez, Sharada Swaminathan, Linh Thuy, Louis‐Philippe Leroux, Maritza Jaramillo, Albert Descoteaux, Simona Stäger
Abstract
Leishmania donovani is a causative agent of visceral leishmaniasis, a potentially lethal disease characterized by strong B cell activation and the subsequent excessive production of nonprotective antibodies, which are known to worsen the disease. How Leishmania activates B cells is still unknown, particularly because this parasite mostly resides inside macrophages and would not have access to B cells during infection.
Topics & Concepts
Leishmania donovaniLeishmaniaLeishmaniasisVisceral leishmaniasisImmunologyBiologyParasite hostingB cellAntibodyVirologyDiseaseCell biologyMedicineWorld Wide WebPathologyComputer scienceResearch on Leishmaniasis StudiesToxin Mechanisms and ImmunotoxinsSynthesis and Biological Evaluation