Design and characterisation of casein coated and drug loaded magnetic nanoparticles for theranostic applications
Christina Wenck, Nils Meier, Eilien Heinrich, Verena Grützner, Frank Wiekhorst, Regina Bleul
Abstract
for Na-caseinate coated MNP. Furthermore, the Na-caseinate coating of MNP increased their salt stability, under unchanged magnetic behaviour. Drug loading (up to ∼75%) and release kinetics such as the delivery into cutaneous squamous cell carcinoma cells (SCL-1) was shown. Our results demonstrate that casein coated MNP are highly promising candidates for theranostic applications in drug delivery, magnetic hyperthermia and magnetic particle imaging.
Topics & Concepts
Magnetic nanoparticlesMaterials scienceMagnetic hyperthermiaDrug deliveryNanoparticleNanotechnologyMagnetic particle inspectionMagnetometerChemical engineeringMagnetic fieldEngineeringQuantum mechanicsPhysicsCharacterization and Applications of Magnetic NanoparticlesProteins in Food SystemsBlood properties and coagulation