A multifunctional targeted nanoprobe with high NIR-II PAI/MRI performance for precise theranostics of orthotopic early-stage hepatocellular carcinoma
Linyun He, Yachao Zhang, Jiangbo Chen, Gongyuan Liu, Jingyi Zhu, Xiaozhen Li, Dengfeng Li, Yuqi Yang, Chun‐Sing Lee, Jiahai Shi, Chao Yin, Puxiang Lai, Lidai Wang, Chihua Fang
Abstract
-MRI demonstrated clear imaging contrast and a spatial relationship between micro-HCC and adjacent structures for a comprehensive description of the tumor. Moreover, when using the targeted nanoprobe, the non-invasively targeted PTT of orthotopic early HCC was carried out under reliable dual-modal imaging guidance with remarkable anti-tumor efficiency and biosafety. This study provides an insight for constructing a multifunctional targeted nanoplatform for precise and comprehensive theranostics of early-stage HCC, which would greatly benefit the patients in the era of precision medicine.