Targeted deletion of Interleukin-3 results in asthma exacerbations
Julia Kölle, Theodor Zimmermann, Alexander Kiefer, Ralf J. Rieker, Paraskevi Xepapadaki, Sebastian Zundler, Nikolaos G. Papadopoulos, Susetta Finotto
Abstract
asthmatic mice showed increased asthmatic traits. Moreover, IL-3-deficient mice had a defect in T regulatory cells in the lung. In conclusion, IL-3 downregulation was found associated with more severe allergic asthma in pre-school children. Consistently, targeting IL-3 resulted in an induced pathophysiological response in a murine model of allergic asthma.
Topics & Concepts
ImmunologyAsthmaPeripheral blood mononuclear cellSecretionMedicineCytokineInterleukin 13PhenotypeInterleukin 4Downregulation and upregulationInterleukin 10InterleukinIn vitroBiologyInternal medicineGeneBiochemistryAsthma and respiratory diseasesIL-33, ST2, and ILC PathwaysAllergic Rhinitis and Sensitization