High-throughput matrix-assisted laser desorption/ionization time-of-flight (MALDI-TOF) mass spectrometry–based deubiquitylating enzyme assay for drug discovery
Virginia De Cesare, Jennifer L. Moran, Ryan Traynor, Axel Knebel, Maria Stella Ritorto, Matthias Trost, Hilary McLauchlan, C. James Hastie, Paul Davies
Topics & Concepts
Drug discoveryMass spectrometryHigh-throughput screeningComputational biologyMatrix-assisted laser desorption/ionizationUbiquitinChemistryTime-of-flight mass spectrometryChromatographyBiologyBiochemistryDesorptionIonizationGeneAdsorptionOrganic chemistryIonUbiquitin and proteasome pathwaysProtein Degradation and InhibitorsAutophagy in Disease and Therapy