AAV-mediated rescue of Eps8 expression in vivo restores hair-cell function in a mouse model of recessive deafness
Jing‐Yi Jeng, Adam J. Carlton, Richard J. Goodyear, Colbie R. Chinowsky, Federico Ceriani, Stuart L. Johnson, Tsung-Chang Sung, Yelena Dayn, Guy P. Richardson, Michael R. Bowl, Steve D. M. Brown, Uri Manor, Walter Marcotti
Abstract
hair cells appear to have matured or accumulated damage beyond the point of repair.
Topics & Concepts
Stereocilia (inner ear)Hair cellTransduction (biophysics)Cell biologyKinociliumBiologyIn vivoInner earAnatomyBiophysicsGeneticsHearing, Cochlea, Tinnitus, GeneticsVestibular and auditory disordersEar Surgery and Otitis Media