Selective Oxidation of Benzylic C–H Bonds Catalyzed by Cu(II)/{PMo<sub>12</sub>}
Peihe Li, Yingying Wang, Xia Wang, Yin Wang, Ying Liu, Keke Huang, Jing Hu, Limei Duan, Changwen Hu, Jinghai Liu
Abstract
-butanol radical intermediate for the selective oxidation of benzylic C-H bonds. The reaction shows a broad range of substrates (benzyl methylene, benzyl alcohols) with good functional group tolerance and chemical selectivity. The corresponding carbonyl compounds were synthesized with good yields under mild conditions. DFT calculations and experimental analysis further demonstrated a reasonable carbon radical mechanism for this type of organic transformation reaction.
Topics & Concepts
CatalysisChemistryMedicinal chemistryOrganic chemistryPolyoxometalates: Synthesis and ApplicationsCatalytic C–H Functionalization MethodsOxidative Organic Chemistry Reactions