A causal relationship between childhood obesity and risk of osteoarthritis: results from a two-sample Mendelian randomization analysis
Ziqin Cao, Yudi Wu, Qiangxiang Li, Yajia Li, Jianhuang Wu
Abstract
PURPOSE: It has been found that childhood obesity (CO) may play an important role in the onset and progression of osteoarthritis (OA). Thus we conducted this mendelian randomisation analysis (MR) to evaluate the causal association between childhood obesity and osteoarthritis. METHODS: test were used to confirm the heterogeneity and pleiotropy of identified IVs, then five different models, including the inverse variance weighted model (IVW), weighted median estimator model (WME), weighted model-based method (WM), MR-Egger regression model (MER), and MR-Robust Adjusted Profile Score (MRAPS) were applied in this MR analysis. RESULTS: ). The accuracy and robustness of these findings were confirmed by sensitivity tests. CONCLUSION: There appears to be a causal relationship between childhood obesity and OA. Our results indicate that individuals with a history of childhood obesity require specific clinical attention to prevent the development of knee and hip OA.