Nuclear receptor PXR targets AKR1B7 to protect mitochondrial metabolism and renal function in AKI
Xiaowen Yu, Man Xu, Xia Meng, Shumin Li, Qianqi Liu, Mi Bai, Ran You, Songming Huang, Li Yang, Yue Zhang, Zhanjun Jia, Aihua Zhang
Abstract
rats, we determined that PXR targeted Aldo-keto reductase family 1, member B7 (AKR1B7) to improve mitochondrial function, thereby ameliorating AKI. We confirmed the protective role of PXR against kidney injury using genomic and pharmacologic approaches in an ischemia/reperfusion model of AKI. These findings demonstrate that disabling the PXR/AKR1B7/mitochondrial metabolism axis is an important factor that can contribute to AKI, whereas reestablishing this axis can be useful for treating AKI.
Topics & Concepts
Pregnane X receptorNuclear receptorFunction (biology)Renal functionAcute kidney injuryChemistryMedicinePharmacologyCell biologyBiologyInternal medicineBiochemistryGeneTranscription factorMetabolism and Genetic DisordersSulfur Compounds in BiologyEicosanoids and Hypertension Pharmacology