An exosomal-carried short periostin isoform induces cardiomyocyte proliferation
Carolina Balbi, Giuseppina Milano, Tudor Emanuel Fertig, Edoardo Lazzarini, Sara Bolis, Yoshiaki Taniyama, Fumihiro Sanada, Dario Di Silvestre, Pierluigi Mauri, Mihaela Gherghiceanu, Thomas F. Lüscher, Lucio Barile, Giuseppe Vassalli
Abstract
Our results show, for the first time, that CPC-secreted exosomes promote cardiomyocyte cell cycle-reentry via a short periostin isoform expressed on their surfaces, whereas recombinant full-length periostin does not. These findings highlight isoform-specific roles of periostin in cardiomyocyte proliferation.
Topics & Concepts
PeriostinGene isoformCell biologyMicrovesiclesCell growthChemistryCancer researchBiologymicroRNAExtracellular matrixBiochemistryGeneCardiac Fibrosis and RemodelingSignaling Pathways in DiseaseCell Adhesion Molecules Research