Chemical technologies for precise protein bioconjugation interfacing biology and medicine
Mohan Kumar, Neelesh C. Reddy, Vishal Rai
Abstract
Proteins provide an excellent means to monitor and regulate biological processes. Hence, a precise chemical toolbox for their modification becomes indispensable. In this perspective, this feature article outlines our efforts to establish the core principles of chemoselectivity, site-selectivity, site-specificity, site-modularity, residue-modularity, and protein-specificity. With the knowledge to systematically regulate these parameters, the field has access to technological platforms that can address multiple challenges at the interface of chemistry, biology, and medicine.
Topics & Concepts
BioconjugationInterfacingChemical biologyReactivity (psychology)ChemistryCombinatorial chemistryComputational biologyPosttranslational modificationNanotechnologyComputer scienceBiochemistryBiologyMaterials scienceMedicineAlternative medicineComputer hardwareEnzymePathologyClick Chemistry and ApplicationsMonoclonal and Polyclonal Antibodies ResearchPeptidase Inhibition and Analysis