Conformation-locking antibodies for the discovery and characterization of KRAS inhibitors
Christopher W. Davies, Angela J. Oh, Rana Mroue, Micah Steffek, John M. Bruning, Yang Xiao, Siyu Feng, Sangeeta Jayakar, Emily Chan, Vidhyalakshmi Arumugam, Sean Carlo Uribe, Jake Drummond, Alexandra Frommlet, Cheng Lu, Yvonne Franke, Mark Merchant, Hartmut Koeppen, John G. Quinn, Sushant Malhotra, Steve Do, Lewis Gazzard, Hans E. Purkey, Joachim Rudolph, Melinda M. Mulvihill, James T. Koerber, Weiru Wang, Marie Evangelista
Topics & Concepts
Small moleculeChemistryComputational biologyDrug discoveryCovalent bondAntibodyIn vivoCombinatorial chemistryBiochemistryKRASProtein–protein interactionBiophysicsPlasma protein bindingMoleculeChemical biologyCharacterization (materials science)Recombinant DNATarget proteinIn vitroProtein structureBinding siteMolecular switchCell biologyPeptide sequenceBispecific antibodyStructural biologyProtein Kinase Regulation and GTPase SignalingHER2/EGFR in Cancer ResearchReceptor Mechanisms and Signaling