Spermidine alleviates cardiac aging by improving mitochondrial biogenesis and function
Junying Wang, Shaoqi Li, Wang Ju, Feixiang Wu, Yuhan Chen, Hao Zhang, Yubo Guo, Lin Yan, Lingxu Li, Xue Yu, Ting Liu, Yajun Zhao
Abstract
-treated) cardiomyocytes. Inhibition of polyamine biosynthesis or SIRT1 activity abolished these effects. PGC-1α knockdown experiments confirmed that SPD activated mitochondrial biogenesis through SIRT1-mediated deacetylation of PGC-1α. These data provide new insight into the antiaging effects of SPD, and suggest potential applicability to protect against deterioration of cardiac function with aging.
Topics & Concepts
Mitochondrial biogenesisTFAMSpermidineNRF1PolyamineDownregulation and upregulationSpermineMitochondrionCell biologySirtuin 1PPARGC1ABiologyCoactivatorOrganelle biogenesisOrnithine decarboxylaseBiogenesisInternal medicineTranscription factorBiochemistryMedicineEnzymeGenePolyamine Metabolism and ApplicationsAutophagy in Disease and TherapySirtuins and Resveratrol in Medicine