Vaccination induces maturation in a mouse model of diverse unmutated VRC01-class precursors to HIV-neutralizing antibodies with >50% breadth
Xuejun Chen, Tongqing Zhou, Stephen D. Schmidt, Hongying Duan, Cheng Cheng, Gwo‐Yu Chuang, Ying Gu, Mark K. Louder, Bob C. Lin, Chen‐Hsiang Shen, Zizhang Sheng, Michelle X. Zheng, Nicole A. Doria‐Rose, Michael Joyce, Lawrence Shapiro, Ming Tian, Frederick W. Alt, Peter D. Kwong, John R. Mascola
Topics & Concepts
Somatic hypermutationVirologyBiologyAntibodyNeutralizing antibodyImmunizationNeutralizationImmunologyB cellHIV Research and TreatmentImmune Cell Function and InteractionT-cell and B-cell Immunology