“Breaking bud”: the effect of direct chemical modifications of phytocannabinoids on their bioavailability, physiological effects, and therapeutic potential
Abhinandan Banerjee, John J. Hayward, John F. Trant
Abstract
, have augmented bioavailability, or demonstrate interesting pharmacological properties in their own right. This review identifies and discusses a subset of these advanced derivatization strategies for the major cannabinoids, where the starting material is the pure phytocannabinoid itself, and the final product either a cannabinoid pro-drug, or a novel pharmacoactive material.
Topics & Concepts
BioavailabilityCannabidiolChemistryDerivatizationCannabinoidNutraceuticalCannabisPharmacologyDrugDronabinolPharmacokineticsChromatographyBiochemistryMass spectrometryPsychiatryMedicineReceptorPsychologyCannabis and Cannabinoid ResearchPsychedelics and Drug StudiesNeurotransmitter Receptor Influence on Behavior