Synthesis of Spiro[5.n (n=6–8)]heterocycles through Successive Ring‐Expansion/Indole C‐2 Functionalization
Yang Yuan, Zixia Guo, Yuanyang Mu, Ye Wang, Murong Xu, Yanzhong Li
Abstract
Abstract A cascade procedure for the efficient and atom‐economical synthesis of spiro[5.n (n=6–8)]heterocycles has been developed. This process goes through the tandem reactions of base‐promoted ring‐expansion of cyclic ketones followed by Cu‐catalyzed intramolecular C‐2 spirocyclization of indoles. Easily accessible starting materials and broad substrate scope are the advantaged features of this protocol. magnified image
Topics & Concepts
ChemistryIntramolecular forceRing (chemistry)Indole testTandemSubstrate (aquarium)CatalysisCascadeCombinatorial chemistrySurface modificationCascade reactionStereochemistryScope (computer science)Organic chemistryChromatographyProgramming languageMaterials scienceOceanographyPhysical chemistryComposite materialGeologyComputer scienceCatalytic C–H Functionalization MethodsOxidative Organic Chemistry ReactionsAsymmetric Synthesis and Catalysis