Peptide-based positron emission tomography probes: current strategies for synthesis and radiolabelling
Mariacristina Failla, Giuseppe Floresta, Vincenzo Abbate
Abstract
Ga) through multiple coordinative bonds can be chemically conjugated to the peptide delivery moiety. The main advantages of these probes are that they are cheaper than classical antibody-based PET tracers and can be efficiently chemically modified to be radiolabelled with virtually any radionuclide making them very attractive for clinical use. The goal of this review is to report and summarize recent technologies in peptide PET-based molecular probes synthesis and radiolabelling with the most used radioisotopes in 2022.
Topics & Concepts
Positron emission tomographyMagnetic resonance imagingPet imagingTomographyPositron emissionNuclear medicinePreclinical imagingPeptideBrain positron emission tomographyChemistryMedical physicsMedicineRadiologyBiochemistryIn vivoBiologyBiotechnologyRadiopharmaceutical Chemistry and ApplicationsPeptidase Inhibition and AnalysisChemical Synthesis and Analysis