Cutting-edge biomaterials for advanced biomedical uses: self-gelation of <scp>l</scp> -arginine-loaded chitosan/PVA/vanillin hydrogel for accelerating topical wound healing and skin regeneration
Rabab M. Ibrahim, Elbadawy A. Kamoun, Noha M. Badawi, Shahira H. EL‐Moslamy, Mahmoud kh., Samar A. Salim
Abstract
biological assays are conducted to confirm the effectiveness of the prepared hydrogel in promoting wound healing and bone regeneration through cytotoxicity assay and wound scratch assay. The composite hydrogels achieved 95% wound healing after 24 hours, attributed to the release of NO from the loaded l-Arg and its essential role in the wound healing process. Consequently, CH-PVA-Van hydrogels emerge as a promising system for loading l-arginine and exhibiting potential for biomedical applications with antibacterial efficacy.
Topics & Concepts
ChitosanVanillinSelf-healing hydrogelsWound healingChemistryRegeneration (biology)Wound dressingPolymer chemistryMaterials scienceOrganic chemistryComposite materialSurgeryMedicineCell biologyBiologyBiochemical and biochemical processesMicroencapsulation and Drying ProcessesBee Products Chemical Analysis