Design and Evaluation of New Quinazolin-4(3<i>H</i>)-one Derived PqsR Antagonists as Quorum Sensing Quenchers in <i>Pseudomonas aeruginosa</i>
Fadi Soukarieh, Alaa Mashabi, William Richardson, Eduard Vico-Oton, Manuel Romero, Shaun N. Roberston, Scott Grossman, Tomás Sou, Ruiling Liu, Nigel Halliday, Irena Kukavica‐Ibrulj, Roger C. Lévesque, Christel A. S. Bergström, Barrie Kellam, Jonas Emsley, Stephan Heeb, Paul Williams, Michael J. Stocks, Miguel Cámara
Abstract
as a potent PqsR inhibitor with potential for hit to lead optimization toward the identification of a PA QS inhibitor which can be advanced into preclinical development.
Topics & Concepts
Quorum sensingPseudomonas aeruginosaVirulenceChemistryMicrobiologyQuorum QuenchingIsothermal titration calorimetryCross-resistanceBiologyBiochemistryBacteriaGeneticsGeneBacterial biofilms and quorum sensingAntimicrobial Resistance in StaphylococcusBacteriophages and microbial interactions