Targeting MYC through WDR5
Lance R. Thomas, Clare M. Adams, Stephen W. Fesik, Christine M. Eischen, William P. Tansey
Abstract
The oncoprotein transcription factor MYC is overexpressed in most cancers and is responsible for hundreds of thousands of cancer deaths worldwide every year. MYC is also a highly validated - but currently undruggable - anti-cancer target. We recently showed that breaking the interaction of MYC with its chromatin co-factor WD repeat-containing protein 5 (WDR5) promotes tumor regression in mouse xenografts, laying the foundation for a new strategy to inhibit MYC in the clinic.
Topics & Concepts
Transcription factorCancer researchChromatinCancerBiologyGeneGeneticsProtein Degradation and InhibitorsGenomics and Chromatin DynamicsCancer-related gene regulation