The Role of Early Life Gut Mycobiome on Child Health
Kayleigh Amber Rodriguez, Manoj Gurung, Rachelanne Talatala, Jolene R Rearick, Meghan L. Ruebel, Kimberly Stephens, Laxmi Yeruva
Abstract
The human gut microbiota is composed of bacteria (microbiota or microbiome), fungi (mycobiome), viruses, and archaea, but most of the research is primarily focused on the bacterial component of this ecosystem. Besides bacteria, fungi have been shown to play a role in host health and physiologic functions. However, studies on mycobiota composition during infancy, the factors that might shape infant gut mycobiota, and implications to child health and development are limited. In this review, we discuss the factors likely shaping gut mycobiota, interkingdom interactions, and associations with child health outcomes and highlight the gaps in our current knowledge of this ecosystem.