Docking study of chloroquine and hydroxychloroquine interaction with RNA binding domain of nucleocapsid phospho-protein – an <i>in silico</i> insight into the comparative efficacy of repurposing antiviral drugs
Muhammad Amin, Ghazanfar Abbas
Abstract
trials of Hydroxychloroquine for the patients infected with . Furthermore, the recommended doses of Hydroxychloroquine may reduce the chances of catching to the healthcare workers and staff who are in contact with or delivering direct care to coronavirus patients as long as they have not been diagnosed with . We further hypothesize that the comparative NTD-N-protein -drug docking interactions may help to understand the comparative efficacy of other candidate repurposing drugs until discovery of a proper vaccine.Communicated by Ramaswamy H. Sarma.
Topics & Concepts
HydroxychloroquineChloroquineVirologyBiologyPlasma protein bindingBinding domainDocking (animal)In silicoCoronavirusViral replicationViral entryBinding siteVirusMedicinePharmacologyBiochemistryImmunologyDiseaseGeneInfectious disease (medical specialty)MalariaNursingCoronavirus disease 2019 (COVID-19)PathologySARS-CoV-2 and COVID-19 ResearchViral Infections and Immunology ResearchCOVID-19 Clinical Research Studies