BECN1<sup>F121A</sup> mutation increases autophagic flux in aged mice and improves aging phenotypes in an organ-dependent manner
Salwa Sebti, Zhongju Zou, Michael U. Shiloh
Abstract
mice were not protected against age-associated hepatic phenotypes but demonstrated reduced skeletal muscle fiber atrophy. These findings identify an organ-specific role for the ability of autophagy to impact organ aging phenotypes.
Topics & Concepts
AutophagyBECN1BiologyPhenotypeSkeletal muscleCell biologyFlux (metallurgy)AgeingSenescenceMutationEndocrinologyInternal medicineGeneticsGeneMedicineApoptosisChemistryOrganic chemistryAutophagy in Disease and Therapy