<i>S</i>-Methyl-<scp>l</scp>-cysteine targeting MsrA attenuates Ang II-induced oxidative stress and atrial remodeling <i>via</i> the p38 MAPK signaling pathway
Beibei Xu, Yinli Xu, Wenpu Ren, Shan Meng, Tao Hong, Zijun Cao, Xiong Xiao, Xiaodong Guo, Liming Yu, Jikai Zhao, Huishan Wang
Abstract
model. SMLC alleviated Ang II-induced cytotoxicity, mitochondrial damage and oxidative stress. Additionally, knockdown MsrA could attenuate the protective effects of SMLC, which were eliminated by the p38 MAPK inhibitor SB203580. In summary, the present study demonstrates that SMLC protects against atrial remodeling in AF by inhibiting oxidative stress through the mediation of the MsrA/p38 MAPK signaling pathway.
Topics & Concepts
MSRAOxidative stressMAPK/ERK pathwayChemistryCell biologyCysteineSignal transductionp38 mitogen-activated protein kinasesBiologyBiochemistryAmino acidEnzymeMethionineReceptor Mechanisms and SignalingCardiac Fibrosis and RemodelingS100 Proteins and Annexins