A chlorin-lipid nanovesicle nucleus drug for amplified therapeutic effects of lung cancer by internal radiotherapy combined with the Cerenkov radiation-induced photodynamic therapy
Pengju Cai, Wenjiang Yang, Zhesheng He, Huiju Jia, Huangwei Wang, Wencong Zhao, Liang Gao, Zhiyong Zhang, Fuping Gao, Xueyun Gao
Abstract
I-BSA@LCN-Apt produced a powerful anti-tumor effect through synergistic radiotherapy and CR-PDT, which almost caused complete tumor growth regression. After treatment, the survival time of the mice was significantly prolonged. During the treatment, no obvious side effects were found by histopathology of important organs, hematology and biochemistry analysis except the decrease of the white blood cell count (WBC). The study provides a major tool for deep-seated tumors to obtain amplified therapeutic effects by synergistic radiotherapy and CR-PDT without the use of any external light source.
Topics & Concepts
Photodynamic therapyRadiation therapyCancer researchLungMedicineBrachytherapyDrugChemistryNuclear medicineInternal medicinePharmacologyOrganic chemistryNanoplatforms for cancer theranosticsPhotodynamic Therapy Research StudiesPorphyrin and Phthalocyanine Chemistry