A case of atopic dermatitis with alopecia universalis in a patient treated with abrocitinib
Jiahui Zhao, Lingling Liu
Abstract
Atopic dermatitis (AD) is sometimes accompanied by alopecia areata (AA) or, in severe cases, alopecia universalis (AU). Preclinical studies have shown that type 1 and type 2 cytokines are involved in AD and AA.1,2 Janus kinase (JAK) inhibitors are effective blockers of JAK/signal transducer and activator of transcription-mediated inflammatory signaling pathways, which regulate multiple cytokines, such as interleukins and interferons.3 A recent case report showed hair regrowth after simultaneous treatment of AU and AD with tofacitinib, a selective inhibitor of JAK 1 and JAK 3.
Topics & Concepts
TofacitinibJanus kinaseAlopecia areataMedicineAlopecia universalisAtopic dermatitisSTAT proteinJanus kinase 1DermatologyImmunologySignal transductionCytokineSTAT3Rheumatoid arthritisChemistryBiochemistryDermatology and Skin DiseasesPsoriasis: Treatment and PathogenesisHair Growth and Disorders