Choline transporter-like proteins 1 and 2 are newly identified plasma membrane and mitochondrial ethanolamine transporters
Adrian Taylor, Sophie Grapentine, Jasmine Ichhpuniani, Marica Bakovic
Abstract
) are devoid of CTL1 ethanolamine transport but maintain unaffected CTL2 transport. The lack of CTL1 in M2 cells reduced the ethanolamine transport, the flux through the CDP-ethanolamine Kennedy pathway, and PE synthesis. In contrast, overexpression of CTL1 in M2 cells improved ethanolamine transport and PE synthesis. These data firmly establish that CTL1 and CTL2 are the first identified ethanolamine transporters in whole cells and mitochondria, with intrinsic roles in de novo PE synthesis by the Kennedy pathway and intracellular redistribution of ethanolamine.
Topics & Concepts
TransporterEthanolamineCholineBiochemistryMembrane transport proteinChemistryMitochondrionMitochondrial carrierTransport proteinBiologyBacterial outer membraneGeneEscherichia coliMetabolism and Genetic DisordersAmino Acid Enzymes and MetabolismMitochondrial Function and Pathology