Cyclic arginine-glycine-aspartic acid-modified red blood cells for drug delivery: Synthesis and in vitro evaluation
Chen Wang, Min Wang, Yan Zhang, Hongxin Jia, Binbin Chen
Abstract
value of unmodified drug-loaded RBCs was 2.5 times higher than that of targeted modified drug-loaded RBCs, indicating that the targeting of cancer cells produced satisfactory inhibition. This study confirms that the RBC DDS has the characteristics of accurate targeting, high drug loading, and slow drug release, which increases its likelihood of becoming a clinical cancer treatment in the future.
Topics & Concepts
ChemistryGlycineAspartic acidIn vitroArginineDrug deliveryBiochemistryDrugCombinatorial chemistryAmino acidPharmacologyOrganic chemistryMedicineErythrocyte Function and PathophysiologyNeonatal Health and BiochemistryHemoglobin structure and function