Salt dependent phase behavior of intrinsically disordered proteins from a coarse-grained model with explicit water and ions
Adiran Garaizar, Jorge R. Espinosa
Abstract
and poly-uridine/poly-arginine mixtures, finding good agreement with their reported in vitro phase behavior with salt concentration in both cases. Taken together, our work represents a step forward towards extending sequence-dependent CG models to include water and salt, and to consider their key role in biomolecular condensate self-assembly.
Topics & Concepts
Chemical physicsSalt (chemistry)Radius of gyrationChemistryMolecular dynamicsIntermolecular forcePhase (matter)BiophysicsBiological systemComputational chemistryMoleculePhysical chemistryPolymerBiologyOrganic chemistryRNA Research and SplicingProtein Structure and DynamicsBacteriophages and microbial interactions