Cycloaddition Reaction of <i>N</i>-Homoallylacetohydrazides with <i>O</i>-Benzoylhydroxylamines under Copper Catalysis: Access to Tetrahydropyridazine Skeletons

Abstract

We present a practical copper-catalyzed strategy for the amination and cyclization of unactivated alkenes. The transformation employs O -benzoylhydroxylamines as alkylamine precursors to initiate a radical cascade process. This protocol enables the construction of a diverse array of tetrahydropyridazine scaffolds by reacting N -homoallylacetohydrazides with O -benzoylhydroxylamines, ultimately affording a total of 25 structurally varied derivatives.

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