Mitochondria-targeted co-assembled nanosystem with multimodal mitochondrial DNA level control to alleviate inflammation and promote chronic wound healing
Xueyan Mao, Chuanwen Wang, Shufan Yu, Kai Zhang, Zheng Wang, Jing Du, Ying Kong, Alberto Bianco, Shaohua Ge, Baojin Ma
Topics & Concepts
MitophagyInflammationMitochondrial DNAMitochondrionWound healingAutophagyMitochondrial permeability transition poreCell biologyDownregulation and upregulationPhenotypeBiologyPathogenesisBioinformaticsDNA damageMedicineCancer researchmitochondrial fusionHomeostasisChronic woundPharmacologyMitochondrial ROSChemistryTumor necrosis factor alphaPINK1ImmunologyInflammatory responseDNA repairCytoplasmMechanism (biology)DNAinterferon and immune responsesAutophagy in Disease and TherapyInflammasome and immune disorders