Nox2 signaling and muscle fiber remodeling are attenuated by losartan administration during skeletal muscle unloading
Jeffrey M. Hord, Marcela Garcia, Katherine R. Farris, Vinícius Guzzoni, Yang Lee, Matthew S. Lawler, John M Lawler
Abstract
) (CONL), 7 days of tail-traction hindlimb unloading (HU), and HU + losartan (HUL). Losartan attenuated unloading-induced loss of muscle fiber cross-sectional area (CSA) and fiber-type shift. Losartan mitigated unloading-induced elevation of ROS levels and upregulation of Nox2. Furthermore, AT1R blockade abrogated nNOS dislocation away from the sarcolemma and elevation of nuclear FoxO3a. We conclude that AT1R blockade attenuates disuse remodeling by inhibiting Nox2, thereby lessening nNOS dislocation and activation of FoxO3a.
Topics & Concepts
Skeletal muscleLosartanMedicineInternal medicineMuscle fibreEndocrinologyAngiotensin IIReceptorMuscle Physiology and DisordersExercise and Physiological ResponsesAdipose Tissue and Metabolism