The group II mGlu receptor antagonist LY341495 induces a rapid antidepressant-like effect and enhances the effect of ketamine in the chronic unpredictable mild stress model of depression in C57BL/6J mice
Agnieszka Pałucha-Poniewiera, Karolina Podkowa, Anna Rafało-Ulińska
Topics & Concepts
KetamineBehavioural despair testPharmacologyAntidepressantNMDA receptorAntagonistGlutamatergicMetabotropic glutamate receptorMetabotropic receptorGlutamate receptorMedicinePsychologyHippocampusNeuroscienceReceptorAnesthesiaInternal medicineTreatment of Major DepressionNeuroscience and Neuropharmacology ResearchTryptophan and brain disorders