Design, synthesis, biological screening and molecular docking studies of novel multifunctional 1,4-di (aryl/heteroaryl) substituted piperazine derivatives as potential antitubercular and antimicrobial agents
Bruktawit Mekonnen Sanka, Dereje Mamo Tadesse, Endale Teju Bedada, Ephriem Mengesha, Neelaiah Babu G.
Topics & Concepts
ChemistryPiperazineDocking (animal)AntimicrobialArylStereochemistryCombinatorial chemistryLead compoundCytotoxicityProtein Data Bank (RCSB PDB)In vitroOrganic chemistryBiochemistryAlkylMedicineNursingSynthesis and biological activityCancer therapeutics and mechanismsQuinazolinone synthesis and applications