Comparative NMR metabolomics of the responses of A2780 human ovarian cancer cells to clinically established Pt-based drugs
Veronica Ghini, Francesca Magherini, Lara Massai, Luigi Messori, Paola Turano
Abstract
, cisplatin, carboplatin and oxaliplatin. Notably, NMR analysis revealed some moderate and consistent changes in the metabolomic profiles of A2780 cells treated with the 3 Pt drugs with respect to controls, but only very small differences among them. Beyond alterations at the level of nucleic acid precursors, the observed changes highlight in all cases the induction of a significant endoplasmic reticulum stress. Owing to the clinical relevance of platinum resistance, the behavior of a cisplatin resistant A2780 cancer cell line upon cisplatin treatment was also evaluated.
Topics & Concepts
MetabolomicsCisplatinOvarian cancerEndoplasmic reticulumChemistryCancerOxaliplatinCancer cellCancer researchPharmacologyBiochemistryBiologyBioinformaticsComputational biologyMedicineInternal medicineChemotherapyColorectal cancerDrug Transport and Resistance MechanismsMetal complexes synthesis and propertiesAdvanced NMR Techniques and Applications