The Metabolic Adaptation in Response to Nitrate Is Critical for Actinobacillus pleuropneumoniae Growth and Pathogenicity under the Regulation of NarQ/P
Qiuhong Zhang, Hao Tang, Chaoyue Yan, Weiyao Han, Lu Peng, Jiajia Xu, Xiabing Chen, Paul R. Langford, Weicheng Bei, Qi Huang, Rui Zhou, Lu Li
Abstract
, suggesting that Nap is a potential drug target. These results give new insights into how the respiratory pathogen A. pleuropneumoniae utilizes the alternative electron acceptor nitrate to overcome the hypoxia microenvironment, which can occur in the inflammatory or necrotic infected tissues.
Topics & Concepts
Actinobacillus pleuropneumoniaeBiologyMicrobiologyVirulenceNitrate reductaseBacteriaNitrateBiochemistryGeneSerotypeGeneticsEcologyMicrobial infections and disease researchAquaculture disease management and microbiotaBacteriophages and microbial interactions