HOTAIR drives autophagy in midbrain dopaminergic neurons in the substantia nigra compacta in a mouse model of Parkinson’s disease by elevating NPTX2 <i>via</i> miR-221-3p binding
Yue Lang, Yu Li, Haojia Yu, Lulu Lin, Xingchi Chen, Sainan Wang, Hui Zhang
Abstract
. In summary, down-regulation of HOTAIR could potentially inhibit the autophagy of dopaminergic neurons in the substantia nigra compacta in a mouse model of PD, thus saving the demise of dopaminergic neurons.
Topics & Concepts
Substantia nigraPars compactaMidbrainDopaminergicNeuroscienceParkinson's diseaseAutophagyBiologyDiseaseDopamineMedicineInternal medicineCentral nervous systemGeneticsApoptosisRNA regulation and diseaseAutophagy in Disease and TherapyNuclear Receptors and Signaling