ACE2 the Janus-faced protein – from cardiovascular protection to severe acute respiratory syndrome-coronavirus and COVID-19
Rhian M. Touyz, Hongliang Li, Christian Delles
Abstract
Angiotensin converting enzyme 2 (ACE2) is the major enzyme responsible for conversion of Ang II into Ang-(1-7). It also acts as the receptor for severe acute respiratory syndrome (SARS)-coronavirus (CoV)-2, which causes Coronavirus Disease (COVID)-19. In recognition of the importance of ACE2 and to celebrate 20 years since its discovery, the journal will publish a focused issue on the basic science and (patho)physiological role of this multifunctional protein.
Topics & Concepts
CoronavirusAngiotensin-converting enzyme 2Coronavirus disease 2019 (COVID-19)PandemicSevere acute respiratory syndrome coronavirus 2 (SARS-CoV-2)2019-20 coronavirus outbreakMedicineRespiratory systemSevere acute respiratory syndromeVirologyReceptorDiseaseImmunologyInternal medicineInfectious disease (medical specialty)OutbreakRenin-Angiotensin System StudiesHormonal Regulation and HypertensionCOVID-19 Clinical Research Studies