AIBN-Induced Remote Trifluoromethyl-Alkynylation of Thioalkynes
Zhimin Xiong, Fang Zhang, Yongqi Yu, Ze Tan, Gangguo Zhu
Abstract
A novel α,α′-azobis(isobutyronitrile) (AIBN)-induced remote trifluoromethyl-alkynylation of thioalkynes with alkynyl triflones as both the trifluoromethyl and alkyne sources is described. Structurally diverse trifluoromethylated (Z)-enynes can be constructed with full control of regio-, stereo-, and site-selectivity, which serves as a highly selective method for the rapid construction of trifluoromethylated molecules.
Topics & Concepts
ChemistryAlkynylationTrifluoromethylCombinatorial chemistryOrganic chemistryCatalysisAlkylFluorine in Organic ChemistrySulfur-Based Synthesis TechniquesCarbohydrate Chemistry and Synthesis