Imaging and therapeutic applications of Zn(<scp>ii</scp>)-cryptolepine–curcumin molecular probes in cell apoptosis detection and photodynamic therapy
Qi‐Pin Qin, Zu‐Zhuang Wei, Zhenfeng Wang, Xiaoling Huang, Ming‐Xiong Tan, Hua‐Hong Zou, Hong Liang
Abstract
] (BQ-Zn) and [Zn(BQ)(Cur)]Cl (BQCur-Zn), were developed for the simple and fluorescent label-free detection of apoptosis, an important biological process. The probes could synergistically promote mitochondrion-mediated apoptosis and enhance tumor therapeutic effects in vitro and vivo.
Topics & Concepts
Photodynamic therapyCurcuminApoptosisChemistryFluorescenceCancer researchCombinatorial chemistryPharmacologyBiochemistryMedicineOrganic chemistryOpticsPhysicsSynthesis and bioactivity of alkaloidsPorphyrin and Phthalocyanine ChemistryCurcumin's Biomedical Applications