Apatinib inhibits cell proliferation and migration of osteosarcoma via activating LINC00261/miR-620/PTEN axis
Gang Han, Quanyi Guo, Ning Ma, Wenzhi Bi, Meng Xu, Jinpeng Jia
Abstract
tumorigenesis of OS through LINC00261/miR-620/PTEN axis. Apatinib-enhanced LINC00261 restrained OS via miR-620/PTEN axis, indicating LINC00261 might promote the efficacy of Apatinib on OS.
Topics & Concepts
ApatinibPTENTensinCancer researchBiologyCell growthmicroRNAGene silencingOsteosarcomaCarcinogenesisTransfectionCell biologyMolecular biologyCell cultureSignal transductionCancerGenePI3K/AKT/mTOR pathwayBiochemistryGeneticsCancer-related molecular mechanisms researchMicroRNA in disease regulationCircular RNAs in diseases