Novel 5-HT<sub>7</sub> receptor antagonists modulate intestinal immune responses and reduce severity of colitis
Yun Han Kwon, Benjamin E. Blass, Huaqing Wang, Jensine A. Grondin, Suhrid Banskota, Kenneth R. Korzekwa, Min Ye, John Gordon, Dennis Colussi, Kevin M. Blattner, Daniel J. Canney, Waliul I. Khan
2024American Journal of Physiology-Gastrointestinal and Liver Physiology10 citationsDOIOpen Access PDF
Abstract
This study demonstrates that the novel highly selective 5-HT 7 receptor antagonists, MC-170073 and MC-230078, significantly alleviated the severity of colitis across models of experimental colitis. These findings suggest that inhibition of 5-HT 7 receptor signaling by these new antagonists may serve as an alternative mode of treatment to diminish symptomology in those with inflammatory bowel disease.
Topics & Concepts
Immune systemColitisReceptorMedicineImmunologyInternal medicineGastrointestinal motility and disordersGastroesophageal reflux and treatmentsHelicobacter pylori-related gastroenterology studies