Increased SGK1 activity potentiates mineralocorticoid/NaCl-induced kidney injury
Catalina Sierra‐Ramos, Silvia Velázquez-García, Ayse G. Keskus, Arianna Vastola-Mascolo, Ana Elena Rodríguez‐Rodríguez, Sergio Luis‐Lima, Guadalberto Hernández, Juan F. Navarro‐González, Esteban Porrini, Özlen Konu, Diego Álvarez de la Rosa
Abstract
Increased activity of the protein kinase serum and glucocorticoid-regulated kinase 1 may be a risk factor for accelerated renal damage. Serum and glucocorticoid-regulated kinase 1 expression could be a marker for the rapid progression toward chronic kidney disease and a potential therapeutic target to slow down the process.
Topics & Concepts
SGK1EndocrinologyInternal medicineMineralocorticoidMineralocorticoid receptorAldosteroneKidneyGlucocorticoidMedicineKidney diseaseFibrosisEpithelial sodium channelChemistrySodiumOrganic chemistryHormonal Regulation and HypertensionIon Transport and Channel RegulationBirth, Development, and Health