Exploration of anti-inflammatory activity of pyrazolo[3,4-d]pyrimidine/1,2,4-oxadiazole hybrids as COX-2, 5-LOX and NO release inhibitors: Design, synthesis, in silico and in vivo studies
M. Abdel Aziz, Ibrahim M. Salem, Mohammed A. AlAwadh, Abdulrahman S. Alharbi, Deiaa E Elsayed Abouzed, Rasha M. Allam, Osama A. A. Ahmed, Tarek S. Ibrahim, Gamal El‐Din A. Abuo‐Rahma, Mamdouh F. A. Mohamed
Topics & Concepts
ChemistryIn silicoOxadiazolePyrimidineIn vivoIn vitroPharmacologyCombinatorial chemistryBiochemistryComputational biologyStereochemistryOrganic chemistryGeneticsGeneMedicineBiologySynthesis and biological activitySynthesis and Characterization of Heterocyclic CompoundsSynthesis and Reactions of Organic Compounds