Qiliqiangxin improves cardiac function and attenuates cardiac remodelling in doxorubicin-induced heart failure rats
Xutao Sun, Guozhen Chen, Ying Xie, Deyou Jiang, Jieru Han, Fei Chen, Yunjia Song
Abstract
The beneficial effects of QL on DOX-induced CHF in rats are mediated by reduction in myocardial fibrosis, promotion of TGF-β3/Smad7, and inhibition of TGF-β1/Smad3. QL may also modulate specific miRNAs. These results provide evidence that QL might be an effective treatment for DOX-induced CHF.
Topics & Concepts
Heart failureDoxorubicinMedicineContext (archaeology)CaptoprilCardiotoxicityCardiac function curveInternal medicinePharmacologyConcomitantChemotherapyBiologyBlood pressurePaleontologyInflammation biomarkers and pathwaysCardiac Fibrosis and RemodelingChemotherapy-induced cardiotoxicity and mitigation