Synthesis of novel piperazine-based bis(thiazole)(1,3,4-thiadiazole) hybrids as anti-cancer agents through caspase-dependent apoptosis
Doaa M. Mohamed, Nabila A. Kheder, Marwa Sharaky, Mohamed S. Nafie, Kamal M. Dawood, Ashraf A. Abbas
Abstract
= 1.3 nM, 97.8% inhibition). Compound 9i dramatically induced apoptotic cell death by 4.16-fold and necrosis cell death by 4.79-fold. Compound 9i upregulated the apoptosis-related genes and downregulated the Bcl-2 as an anti-apoptotic gene. Accordingly, the most promising EGFR-targeted chemotherapeutic agent to treat colon cancer was found to be compound 9i.
Topics & Concepts
ThiazolePiperazineApoptosisChemistryHybridCaspase 3Combinatorial chemistryPharmacologyStereochemistryBiologyBiochemistryOrganic chemistryProgrammed cell deathBotanySynthesis and biological activitySynthesis and Biological EvaluationClick Chemistry and Applications