Charge neutralized poly(β-amino ester) polyplex nanoparticles for delivery of self-amplifying RNA
Nazgol Karimi Dastgerdi, Nurcan Gümüş, Hulya Bayraktutan, Darryl Jackson, Krunal Polra, Paul F. McKay, Fatemeh Atyabi, Rassoul Dinarvand, Robin J. Shattock, Luisa Martínez‐Pomares, Pratik Gurnani, Cameron Alexander
Abstract
Therapeutic self-amplifying RNA (saRNA) is a promising approach for disease treatment, as it can be administered in lower doses than messenger RNA (mRNA) to achieve comparable protein production levels.
Topics & Concepts
RNAChemistryNanoparticlePolymer chemistryBiophysicsMaterials scienceNanotechnologyBiochemistryBiologyGeneRNA Interference and Gene DeliveryBiopolymer Synthesis and ApplicationsAdvanced biosensing and bioanalysis techniques