PARP inhibitor BMN-673 induced apoptosis by trapping PARP-1 and inhibiting base excision repair via modulation of pol-β in chromatin of breast cancer cells
Chinmayee Sethy, Chanakya Nath Kundu
Topics & Concepts
Poly ADP ribose polymerasePARP inhibitorChromatinCancer researchDNA repairTransfectionApoptosisMolecular biologyCancer cellDNA damageChemistryBiologyCancerDNAPolymeraseCell cultureBiochemistryGeneticsPARP inhibition in cancer therapyDNA Repair MechanismsPlant Genetic and Mutation Studies